Huygens Deconvolution works well on high to very low signal data as the MLE algorithms effectively remove noise while improving contrast. This means that the acquisition time can be decreased without loss of information in the final image. A big benefit is then that the sampling rate can be increased without time loss or risk of photobleaching due to prolonged light exposure. Experimental evidence can be found in the whitepaper on quantitative analysis of deconvolution results.
